In a medium bowl, whisk together the mayo, vinegar, and lemon juice until smooth.
Add horseradish, Dijon, Worcestershire, and hot sauce. Whisk to combine.
Season with garlic powder, onion powder, salt, and black pepper.
Taste and adjust: add more vinegar for tang, more horseradish for bite, or a touch of sugar/honey to round the acidity.
Refrigerate at least 30 minutes to let the flavors settle. Sauce thickens slightly as it chills.
Use as a dunking sauce for smoked chicken, a finishing glaze, or a marinade to keep poultry juicy.